Development of a cell analysis algorith for lens-free microscopy H/F
Commissariat A Le Energie Atomique
Grenoble, Auvergne-Rhône-Alpes, France
il y a 18j

Organisation

The French Alternative Energies and Atomic Energy Commission (CEA) is a key player in research, development and innovation in four main areas :

  • defence and security,
  • nuclear energy (fission and fusion),
  • technological research for industry,
  • fundamental research in the physical sciences and life sciences.
  • Drawing on its widely acknowledged expertise, and thanks to its 16000 technicians, engineers, researchers and staff, the CEA actively participates in collaborative projects with a large number of academic and industrial partners.

    The CEA is established in ten centers spread throughout France

    Description de l'unité

    The French Alternative Energies and Atomic Energy Commission (CEA) is a key player in research, development and innovation in four main areas :

  • defence and security,
  • nuclear energy (fission and fusion),
  • technological research for industry,
  • fundamental research in the physical sciences and life sciences.
  • Drawing on its widely acknowledged expertise, and thanks to its 16000 technicians, engineers, researchers and staff, the CEA actively participates in collaborative projects with a large number of academic and industrial partners.

    The CEA is established in ten centers spread throughout France

    Job title

    Development of a cell analysis algorith for lens-free microscopy H / F

    Socio-professional category

    Executive

    Contract duration (months)

    1 year (1 year renewable)

    Job description

    The Laboratory of Imaging and Acquisition Systems (LISA) at CEA Grenoble has an opening for setting up a cell analysis algorithm.

    At CEA-Leti we have validated a video-lens-free microscopy platform by performing thousands of hours of real-time imaging observing varied cell types and culture conditions (e.

    g. : primary cells, human stem cells, fibroblasts, endothelial cells, epithelial cells, 2D / 3D cell culture, etc.). And we have developed different algorithms to study major cell functions, i.

    e. cell adhesion and spreading, cell division, cell division orientation, and cell death. In the frame of the current project, we will extend the analysis of the datasets produced by lens-

    free video microscopy by implementing a real-time cell tracking algorithm to follow every single cell and to plot different cell fate events as a function of time.

    The postdoctoral scholar will be responsible for developing a cell tracking and cell segmentation algorithm and assess the novel microscopy technique in the realms of live cell culture imaging.

    To develop and assess this cell analysis software platform, the postdoctoral scholar will conduct three distinctive tasks.

    The first task is dedicated to the definition and the acquisition of a reference dataset. The second task will deal with the development of dedicated algorithms, namely a cell detection algorithm, a quantitative cell segmentation algorithm and a cell tracking and lineage algorithms.

    The last task deals with the exhaustive assessment of the methodology on different cell lines and experimental conditions.

    Offer :

  • Access to top class research facilities.
  • Work on an interdisciplinary project in a team of motivated researchers with diverse backgrounds.
  • full time contract, starting December 2017.
  • Salary : 30 000 - 35 000 euros / year depending on candidate qualifications.
  • Grenoble is located close to a large number of outdoor activities.
  • Requirements :

  • PhD degree in physical sciences, or engineering.
  • Solid background in image processing of cell culture acquisitions
  • Successful experience working in a bio-imaging group.
  • Strong interest for applications of optics in the life sciences.
  • Fluent in French, and / or English (oral and written), clear and effective communication skills.
  • Job location

    France, Auvergne-Rhône-Alpes

    01 / 12 / 2017

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